Dr. Charles Serhan presented the 2023 Mohamed Naguib Lecture on the topic of: General Introduction on the Role of Pro-resolving Mediators (SPMs).
Professor Charles N. Serhan holds the Gelman Professorship Harvard Medical School, is Director of the Center for Experimental Therapeutics and Reperfusion Injury and Professor of Oral Medicine, Infection and Immunity, Harvard University, Boston, MA.
Research in Dr. Serhan’s laboratory focuses on structural elucidation of bioactive small molecules that activate the resolution of acute inflammation. The overall mission is “To identify novel mediators, pathways, and cellular targets critical in promoting resolution of inflammation and reperfusion tissue injury and their relation to human disease.”
His studies currently focus on structural elucidation of novel molecules and pathways that serve as pro-resolving and/or endogenous anti-inflammatory chemical signals. He elucidated several new families of lipid-derived, local-acting chemical mediators, coined the Resolvins and Protectins, and most recently Maresins, that stimulate resolution of inflammatory responses. He also designed novel therapeutic approaches using these structures as biotemplates. New therapeutic approaches built with the knowledge of these signaling pathways could be more potent, selective and better tolerated since they are based on structures naturally evolved in these processes. Several of these new designer therapeutics have already been shown to be effective in human disease.
International Society of Anaesthetic Pharmacology (ISAP), established the Mohamed Naguib Lecture to honor the late Dr. Mohamed Naguib. Dr. Naguib had a distinguished career in the field of anesthesiology and was a long supporter of ISAP, serving as President of the society. He made significant contributions to the scientific foundation and clinical applications of neuromuscular monitoring. This named lecture is given at each ISAP Annual Meeting.